Endocrine Abstracts

The somatostatin receptor 5 (sst5) and its truncated splicing variants (sst5TMD5, sst5TMD4) are considered putative biomarkers that can predict pharmacological response or aggressiveness in several endocrine-related pathologies, such as acromegaly. sst5 is encoded by a gene, SSTR5, that lacks introns within its coding sequence, and hence, the splicing variants identified are generated by non-canonical splicing events. However, the mechanisms underlying their genesis a...

Craniopharyngiomas (CP) are low-prevalent tumors characterized for their local invasiveness and poor clinical outcomes, often requiring aggressive therapeutic measures. Ki67 is a marker of proliferation with good correlation with tumor recurrence in many solid tumors but this relationship is unclear in CP. Our aim is to determine whether Ki67 could be a marker for recurrence in CP.Material and methods: Descriptive retrospective observational study. All p...

ObjectiveTo study the possible relationship between adherence to the Mediterranean diet and the metabolic syndrome. Material and methods: Retrospective observational study of patients evaluated in a prebariatric surgery consultation between November 2017 and November 2019, who were given a questionnaire of adherence to a Mediterranean diet. Anthropometric and analytical parameters related to the metabolic syn...

Procalcitonin (PCT) is a sepsis diagnostic marker and mortality predictor, although its elevation can be related to other diseases such as medullary thyroid carcinoma (MTC). A 72-year-old woman was transferred to the intensive care unit of our institution from another center. One week before, she had been admitted with a clinical picture of progressive malaise, fever, and dyspnea. Weeks before her admission, she had consulted for dyspnea, anorexia, asthenia, and weight loss. I...

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

Ntroduction and Aim: The use of sodium-glucose cotransporter type 2 (SGLT-2) inhibitors has importantly improved the management of patients with type 2 diabetes mellitus. The aim of the present study was to evaluate the renal and metabolic effects after one year of SGLT-2 use in a cohort of patients with type 1 diabetes mellitus (T1D) treated with continuous subcutaneous insulin infusion (CSII).Methods: Retrospective observational study in adult patients...

Background and Aim: Data support the use of hybrid closed-loop systems, because of it positive impact in the management of patients with type 1 diabetes (T1D). The aim was to evaluate the impact of an hybrid closed-loop system in patients with T1D at high risk of hypoglycemia.Methods: Retrospective study of patients with T1D controlled in a Endocrinology department older than 17 years old, who were carriers of an Insulin Pump (MiniMed™640G) and Flas...

Introduction: Diabetes mellitus secondary to exocrine pancreas diseases (pancreatogenic DM) is a heterogeneous type of DM that usually requires treatment with multiple doses of insulin (MDI), like type 1 DM (DM1). Our objective was to evaluate the difference in the impact of Flash glucose monitoring (FGM) on glycemic control in pancreatogenic DM and DM1. Methods: Prospective, observational study in Spanish hospital. We included the first patients with DM...

Introduction: Cystic fibrosis-related diabetes (CFRD) has a prevalence of 40-50% in adults. Given what we know about metabolic liver disease, studies are needed to assess whether CFRD is also related to steatosis (LS) and liver fibrosis (LF).Objectives: To determine the prevalence of LS and LF by magnetic resonance elastography (Mre) in a cohort of adults with CFRD. Secondary: to determine the diagnostic yield of transitional elastography (Fibroscan&#174...

Transsphenoidal surgery (TSS) of the hypothalamic-pituitary region is the approach of choice because of its lower morbidity compared to the transcranial approach. However, its results are highly variable and depend on many factors related to the tumor itself, to the medical team, and to technical issues. We review the situation of this procedure in a nationwide retrospective multicenter evaluation. Data were collected from centers participating in the TESSPAIN (TranssphEnoidal...